Atlas of Schizophrenia by Martin Stefan

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By Martin Stefan

Written by way of a crew of specialists operating on the leading edge of this box, An Atlas of Schizophrenia describes schizophrenia's profound results on notion, figuring out, verbal exchange, and social habit; its identifiable antecedents in early mind progress and improvement; and its morphological facts from structural mind imaging and autopsy stories. It covers, with examples, the newest study advancements in neuropsychology, psychophysiology, and sensible imaging besides in vivo receptor imaging and different advances in psychopharmacology which are laying off new gentle at the neurochemistry of schizophrenia.

Diagrams, tables, and figures received via smooth imaging suggestions mixed with examples of work from the Bethlem Royal medical institution records and Museum illustrate the human in addition to the medical and psychiatric elements of the affliction. those beneficial properties offer you a whole photograph of schizophrenia, its prognosis, and administration. With its mix of the newest study and scientific info and cutting-edge mind imaging ideas, An Atlas of Schizophrenia presents a special visible presentation of the present knowing of the medical positive factors, etiology, pathophysiology, and healing procedures to be had.

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6). The nigrostriatal tract projects from the substantia nigra in the midbrain to the corpus striatum. This tract primarily has a role in motor control, although the ventral striatum has a role in reward- and goal-directed behaviors. Degeneration of the cells in the substantia nigra leads to idiopathic Parkinson’s disease, and it is by blocking the dopamine receptor at the termination of this pathway that the parkinsonian side-effects of classical antipsychotics arise. The mesolimbic/ mesocortical tract has its cell bodies in the ventral tegmental area adjacent to the substantia nigra.

Some believe that the onset of frank psychotic symptoms reflects the delayed sequelae of an earlier developmental aberration, which is then expressed as the brain continues to develop in adolescence and adult life – sometimes termed the ‘doomed from the womb’ view. Delayed emergence of abnormal behavior following lesions sustained during early development is a well recognized phenomenon, and is seen, for example, in animal models where ventral hippocampal lesions, initially ‘silent’, are followed by hyperactivity and increased responsiveness to stressful stimuli and to dopamine blockade as the animal matures.

Figure reproduced with permission from Bebbington P, Wilkins S, Jones P, et al. Life events and psychosis. Initial results from the Camberwell Collaborative Psychosis Study. Br J Psychiatry 1993;162:72–9 FREQUENCY OF LIFE EVENTS Life event rates per100 subjects 100 Schizophrenia Mania Depressive psychosis Controls 90 80 70 60 50 40 30 20 10 0 1 2 3 4 5 6 Months before onset/interview It is estimated that 20–50% of the population with schizophrenia in Western countries may qualify as substance abusers or ‘dual-diagnosis’ patients.

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